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Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

DOI: 10.1039/c3cc45689g DOI Help

Authors: Andrew Burrows (University of Bath) , Monika Jurcic (University of Bath) , Luke Keenan (University of Bath) , Rebecca A. Lane (University of Bath) , Mary F. Mahon (University of Bath) , Harriott Nowell (Diamond Light Source) , Michael Paradowski (University of Sussex) , John Spencer (University of Sussex) , Mark R. Warren
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications

State: Published (Approved)
Published: October 2013

Abstract: A series of new zinc-based metal–organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

Subject Areas: Chemistry, Medicine, Materials

Instruments: I19-Small Molecule Single Crystal Diffraction

Added On: 22/10/2013 14:59

Discipline Tags:

Drug Delivery Health & Wellbeing Chemistry Materials Science Metal-Organic Frameworks Life Sciences & Biotech Metallurgy Organometallic Chemistry

Technical Tags:

Diffraction Single Crystal X-ray Diffraction (SXRD)