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Structures of adenosine kinase from Trypanosoma brucei brucei

DOI: 10.1107/S2053230X13033621 DOI Help
PMID: 24419613 PMID Help

Authors: Jennifer Timm (University of York) , Dolores González-pacanowska (Instituto deParasitologý´a y Biomedicina ‘Lo´ pez-Neyra') , Keith Wilson (University of York)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Acta Crystallographica Section F Structural Biology Communications , VOL 70 , PAGES 34 - 39

State: Published (Approved)
Published: January 2014

Abstract: Trypanosoma brucei is a single-cellular parasite of the genus Kinetoplastida and is the causative agent of African sleeping sickness in humans. Adenosine kinase is a key enzyme in the purine-salvage pathway, phosphorylating adenosine to AMP, and also activates cytotoxic analogues such as cordycepin and Ara-A by their phosphorylation.

Journal Keywords: Crystallization; Crystallography; X-Ray; Models; Molecular; Protein; Secondary; Substrate; Trypanosoma brucei brucei

Subject Areas: Biology and Bio-materials, Medicine

Instruments: I03-Macromolecular Crystallography , I24-Microfocus Macromolecular Crystallography