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Emerging Patterns in the Distribution of Trace Elements in Ovarian, Invasive and In-Situ Breast Cancer

DOI: 10.1088/1742-6596/499/1/012014 DOI Help

Authors: A. Al-ebraheem (McMaster university) , E. Dao (McMaster university) , K. Geraki (Diamond Light Source) , M. J. Farquharson (McMaster university)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Physics: Conference Series , VOL 499

State: Published (Approved)
Published: April 2014
Diamond Proposal Number(s): 8487

Abstract: Breast cancer is the most common cancer and ovarian cancer is the 8th most common cancer affecting women worldwide. This study highlights the changes of trace element levels accompanied by the progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) of the breast, using micro probe Synchrotron Radiation X-ray Fluorescence (µSRXRF). The average values for the increase in Ca, Fe and Zn in tumour regions with respect to surrounding regions for the DCIS samples were significantly higher compared to the increase in the IDC samples (P <0.01).This study was also carried out to find a connection between ovarian cancer and breast cancer with respect to the cellular distribution of Ca, Cu, Fe, and Zn. For IDC, DCIS and ovarian cases, the statistical analysis reveals a significant increase in the levels of Ca, Cu and Zn concentrations in cancer tissue when compared to the normal surrounding tissue. For Fe, the differences between tumour regions with respect to surrounding regions were found to be not significant in IDC and ovarian cases. In DCIS cases, the results reveal a significant increase in the levels of Fe in cancer tissue when compared to the surrounding normal breast tissue (P <0.01).

Journal Keywords: Animal Tissues; Carcinomas; Concentration Ratio; Distribution; Fluorescence; Mammary Glands; Probes; Spatial Dose Distributions; Synchrotron Radiation; Trace Amounts; Women; X Radiation

Subject Areas: Biology and Bio-materials

Instruments: I18-Microfocus Spectroscopy

Other Facilities: ANKA, Germany