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A New Mechanism for Hydroxyl Radical Production in Irradiated Nanoparticle Solutions

DOI: 10.1002/smll.201400110 DOI Help

Authors: Cécile Sicard-roselli (Paris-Sud University) , Emilie Brun (Paris-Sud University) , Manon Gilles (Paris-Sud University) , Gérard Baldacchino (CEA Saclay, IRAMIS, LIDyl, Physico-Chimie et Rayonnement) , Colin Kelsey (Queen's University of Belfast) , Harold Mcquaid (Queen's University of Belfast) , Christopher Polin (Queen's University of Belfast) , Nathan Wardlow (Queen's University of Belfast) , Fred Currell (Queen's University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Small

State: Published (Approved)
Published: May 2014
Diamond Proposal Number(s): 9104 , 8481 , 8482

Abstract: The absolute yield of hydroxyl radicals per unit of deposited X-ray energy is determined for the first time for irradiated aqueous solutions containing metal nanoparticles based on a “reference” protocol. Measurements are made as a function of dose rate and nanoparticle concentration. Possible mechanisms for hydroxyl radical production are considered in turn: energy deposition in the nanoparticles followed by its transport into the surrounding environment is unable to account for observed yield whereas energy deposition in the water followed by a catalytic-like reaction at the water-nanoparticle interface can account for the total yield and its dependence on dose rate and nanoparticle concentration. This finding is important because current models used to account for nanoparticle enhancement to radiobiological damage only consider the primary interaction with the nanoparticle, not with the surrounding media. Nothing about the new mechanism appears to be specific to gold, the main requirements being the formation of a structured water layer in the vicinity of the nanoparticle possibly through the interaction of its charge and the water dipoles. The massive hydroxyl radical production is relevant to a number of application fields, particularly nanomedicine since the hydroxyl radical is responsible for the majority of radiation-induced DNA damage.

Subject Areas: Chemistry, Physics, Medicine


Instruments: B16-Test Beamline , I15-Extreme Conditions

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