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Side-chain control of porosity closure in single- and multiple-peptide-based porous materials by cooperative folding

DOI: 10.1038/nchem.1871 DOI Help

Authors: C. Martí-gastaldo (University of Liverpool) , D. Antypov (University of Liverpool) , M. E. Briggs (University of Liverpool) , P. A. Chater (University of Liverpool) , P. V. Wiper (University of Liverpool) , Gary Miller (University of Liverpool) , Y. Z. Khimyak (University of Liverpool) , G. R. Darling (University of Liverpool) , N. G. Berry (University of Liverpool) , Matthew Rosseinsky (University of Liverpool) , John Warren (University of Liverpool)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Nature Chemistry , VOL 6 (4) , PAGES 343 - 351

State: Published (Approved)
Published: February 2013
Diamond Proposal Number(s): 7036

Abstract: Porous materials are attractive for separation and catalysis—these applications rely on selective interactions between host materials and guests. In metal–organic frameworks (MOFs), these interactions can be controlled through a flexible structural response to the presence of guests. Here we report a MOF that consists of glycyl–serine dipeptides coordinated to metal centres, and has a structure that evolves from a solvated porous state to a desolvated non-porous state as a result of ordered cooperative, displacive and conformational changes of the peptide. This behaviour is driven by hydrogen bonding that involves the side-chain hydroxyl groups of the serine. A similar cooperative closure (reminiscent of the folding of proteins) is also displayed with multipeptide solid solutions. For these, the combination of different sequences of amino acids controls the framework's response to the presence of guests in a nonlinear way. This functional control can be compared to the effect of single-point mutations in proteins, in which exchange of single amino acids can radically alter structure and function.

Journal Keywords: Metal–organic frameworks; Solid-state chemistry

Subject Areas: Chemistry, Materials


Instruments: I11-High Resolution Powder Diffraction , I19-Small Molecule Single Crystal Diffraction