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Gold Nanoparticles for Imaging and Radiotherapy

DOI: 10.1016/B978-0-08-098338-7.00003-0 DOI Help

Authors: Stephen Mcmahon (Queen's University, Belfast) , Fred Currell (Queen's University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Frontiers Of Nanoscience , VOL 5 , PAGES 5

State: Published (Approved)
Published: September 2013
Diamond Proposal Number(s): 8062

Abstract: The physical mechanisms of action involved when heavy atoms are embedded in biological systems subject to ionising radiation are described with a particular view to providing models for the use of (gold) nanoparticles as targeted agents intended to improve both diagnostic imaging and radiotherapy. Fundamental interactions between ionising radiation and matter are reviewed and then invoked to describe the specific processes arising when nanoparticles containing heavy atoms, and particularly gold nanoparticles, are irradiated in biological systems. Shortcomings in simple macroscopic models of dose distribution are discussed, with the concept of nanodosimetry being used to account for the large effects observed. Finally, some open questions and future research directions are reviewed.

Journal Keywords: Nanoparticle; Radiation; Radiotherapy; X-Ray; Imaging; Gold; Cancer Therapy

Subject Areas: Medicine

Instruments: B16-Test Beamline , I15-Extreme Conditions

Other Facilities: ID17 from ESRF.

Added On: 30/06/2014 11:40

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