Towards understanding P-gp resistance: a case study of the antitumour drug cabazitaxel

DOI: 10.1039/C4CE01279H

Authors: Ulrich Baisch (University of Newcastle Upon Tyne) , Liana Vella-Zarb (University of Malta)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Crystengcomm , VOL 16 (44) , PAGES 10161-10164

State: Published (Approved)
Published: August 2014
Diamond Proposal Number(s): 6749

Abstract: A detailed structural study and Hirshfeld surface analysis of cabazitaxel in its anhydrous, hydrated and solvated forms have revealed that the three-dimensional architecture of the drug molecule is retained regardless of the crystalline environment. This prompted comparison with its taxane predecessors, suggesting key factors contributing to cabazitaxel's poor affinity to P-gp.

Subject Areas: Chemistry, Medicine


Instruments: I19-Small Molecule Single Crystal Diffraction

Added On: 22/09/2014 10:37

Discipline Tags:

Non-Communicable Diseases Health & Wellbeing Cancer Biochemistry Chemistry Life Sciences & Biotech

Technical Tags:

Diffraction Single Crystal X-ray Diffraction (SXRD)