MRI Relaxometry Correlation Against Iron in Alzheimer's Disease

Authors: Christos Michaelides (King's College London) , David Lythgoe (King's College London) , Harry Parkes (Institute of Cancer Research) , Claire Troakes (King's College London) , Istvan Bodi (King's College London) , Tina Geraki (Diamond Light Source) , Amy Herlihy (Agilent Technologies) , Po-wah So (King's College London)
Co-authored by industrial partner: No

Type: Poster

State: Published (Approved)
Published: May 2014

Abstract: Iron dysregulation may be a contributing factor to neuronal cell death in Alzheimer’s disease. MR relaxometry measurements in fixed post-mortem human AD and control samples were correlated with direct iron assessment by synchrotron-radiation X-ray fluorescence mapping. AD did not affect iron concentrations or relaxometry. Whilst R2 and R2* correlated with iron, R1 correlated less well, potentially due to significant effects from fixation time. Increased iron in white compared to grey matter is consistent with elevated iron concentrations within white matter myelin. Our results support R2 and R2* relaxometry in non-invasive assessment of brain iron.

Subject Areas: Biology and Bio-materials

Instruments: I18-Microfocus Spectroscopy