The Ni(II) complex of 2-hydroxy-pyridine-n-oxide 2-isothionate: synthesis, characterization, biological studies, and x-ray crystal structures using (1) Cu Kα data and (2) synchrotron data

DOI: 10.15744/2348-9812.1.301

Authors: Mohamed A. Makhyoun (Alexandria University) , Rex A. Palmer (Birkbeck College, London) , Amina A. Soayed (Alexandria University) , Heba M. Refaat (Alexandria University) , Dina E. Basher (Alexandria University) , James Raftery (University of Manchester) , Carina Lobley (Diamond Light Source) , Anna Warren (Diamond Light Source) , Thomas Sorensen (Diamond Light Source) , Mark Ladd (University of Surrey)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Materials Science And Nanotechnology , VOL 1

State: Published (Approved)
Published: March 2014
Diamond Proposal Number(s): 5814

Abstract: Compounds containing N-oxides and sulphur possess important biological activity. Compounds containing sulphur, as well as their metal complexes exhibit numerous biochemical applications. 2-Hydroxy-pyridine-N-oxide (HOPNO) and 2-mercaptopyridine-N-oxide (HSPNO) have been described as new and efficient transition-state analog (TS-analog) inhibitors for the mushroom tyrosinase enzyme. 2-Hydroxy-pyridine-N-oxide derivatives have been shown to remove iron from human transferrin and horse spleen ferritin at pH 7.4 at levels higher than those caused by desferrioxamine. The intraperitoneal and intragastric administration of 2,4-dihydroxypyridine-N-oxide to iron-loaded 59Fe-labelled mice caused an increase in 59Fe excretion comparable to that caused by intraperitoneal desferrioxamine. These results increase the prospects for the use of these chelators as probes for studying iron metabolism and in the treatment of iron overload and other diseases of iron imbalance [8]. 2-Hydroxy-N-oxide is also now used as a wood preservative to prevent fungal decay and insect attack. Moreover, pyridine N-oxide derivatives are also employed in the oxidation of alkyl halides to aldehydes, due to the relative ease of deoxygenation compared to deoxygenation of tertiary amine oxides.

Journal Keywords: 2-Hydroxy-pyridine-N-oxide derivatives; Infrared; Ultraviolet; DTG (Differential thermo-gravimetric); TGA (Thermo-gravimetric ); DTA (Differential thermal analysis ); X-ray crystal structure: Cu K alpha; and synchrotron data; Biological properties

Subject Areas: Chemistry, Biology and Bio-materials


Instruments: I02-Macromolecular Crystallography

Added On: 06/02/2015 10:05

Documents:
2101-The-Ni(II)-complex-of-2-hydroxy-pyridine-N-oxide-2-isothionate-synthesis-characterization-biological-studies-and-X-ray-crystal-structures-using-(1)-Cu-K-data-and-(2)-synchrotron-data.pdf

Discipline Tags:

Biochemistry Chemistry Structural biology Life Sciences & Biotech

Technical Tags:

Diffraction Macromolecular Crystallography (MX)