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Direct synthesis of PEG-encapsulated gold nanoparticles using branched copolymer nanoreactors

DOI: 10.1039/c4ra03500c DOI Help

Authors: Iain Dunlop (Imperial College London) , Mary P. Ryan (Imperial College London) , Angela Goode (Imperial College London) , Carlos Schuster (Imperial College London) , Nicholas Terrill (Diamond Light Source) , Jonathan V. M. Weaver (Imperial College London)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Rsc Advances , VOL 4 (53)

State: Published (Approved)
Published: June 2014
Diamond Proposal Number(s): 7775

Abstract: We report a method of directly synthesizing gold nanoparticles that are coated with poly(ethylene glycol) (PEG) for applications in biology and medicine. The particles are grown within the cores of micelle-like structures formed by pH-responsive branched copolymers of poly(ethylene glycol) methacrylate (PEGMA) and 2-diethylamino methacrylate (DEAMA). The process is cheap and scalable, with PEGylated gold particles prepared in two straightforward steps from commercially available monomers and salts. The formation of gold nanoparticles with mean size of 45 A ̊ is confirmed by transmission electron microscopy. Kinetic studies of nanoparticle growth by small-angle X-ray scattering (SAXS) show that the particles form slowly over a period of >17 hours. This process can be modified by exposure to high- intensity X-rays, which cause widespread rapid nucleation leading to a larger number of smaller particles.

Subject Areas: Materials, Biology and Bio-materials, Chemistry

Instruments: I22-Small angle scattering & Diffraction

Other Facilities: No.