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The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine

DOI: 10.1039/C4SM02256D DOI Help

Authors: Jaclyn Raeburn (University of Liverpool) , Cristina Mendoza-cuenca (Department of Chemical Engineering, Faculty of Sciences, 18071 Granada) , Beatrice N. Cattoz (University of Sussex) , Marc A. Little (University of Liverpool) , Ann E. Terry (Rutherford Appleton Laboratory) , Andre Zamith Cardoso (University of Liverpool) , Peter C. Griffiths (University of Sussex) , Dave Adams (University of Liverpool)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Soft Matter , VOL 11 (5) , PAGES 927 - 935

State: Published (Approved)
Published: December 2014
Diamond Proposal Number(s): 8728

Open Access Open Access

Abstract: Gels can be formed by dissolving Fmoc–diphenylalanine (Fmoc–PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.

Subject Areas: Chemistry, Materials

Instruments: I19-Small Molecule Single Crystal Diffraction