Formation of DNA-copolymer fibrils through an amyloid-like nucleation polymerization mechanism

DOI: 10.1002/marc.201400728

Authors: Dawid Kedracki (University of Geneva) , Sergey K. Filippov (Institute of Macromolecular Chemistry, Prague) , Nidhi Gour (University of Geneva) , Helmut Schlaad (University of Potsdam) , Corinne Nardin (University of Geneva)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Macromolecular Rapid Communications , VOL 36 (8) , PAGES 768 - 773

State: Published (Approved)
Published: February 2015
Diamond Proposal Number(s): 10051

Abstract: Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes.

Journal Keywords: Dna Copolymers; Fibers; Hydrogen Bonding; Nucleation Polymerization; Self-Assembly

Subject Areas: Chemistry, Materials, Biology and Bio-materials


Instruments: B21-High Throughput SAXS

Other Facilities: BM26B at ESRF

Added On: 13/03/2015 10:59

Discipline Tags:

Biomaterials Chemistry Materials Science Polymer Science

Technical Tags:

Scattering Small Angle X-ray Scattering (SAXS)