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Coagulation factor XII protease domain crystal structure

DOI: 10.1111/jth.12849 DOI Help
PMID: 25604127 PMID Help

Authors: Monika Pathak (University of Nottingham) , P. Wilmann (University of Nottingham) , J. Awford (University of Nottingham) , C. Li (University of Nottingham) , B. K. Hamad (University of Nottingham) , P. M. Fischer (University of Nottingham) , Ingrid Dreveny (University of Nottingham) , L. V. Dekker (University of Nottingham) , Jonas Emsley (University of Nottingham)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Thrombosis And Haemostasis

State: Published (Approved)
Published: March 2015
Diamond Proposal Number(s): 10369

Open Access Open Access

Abstract: Coagulation factor XII is a serine protease that is important for kinin generation and blood coagulation, cleaving the substrates plasma kallikrein and FXI.

Journal Keywords: Active Site; Catalytic Domain; Factor Xii; Plasma Prokallikrein; Tertiary Protein Structure; Zymogens

Subject Areas: Medicine, Biology and Bio-materials, Chemistry


Instruments: I04-Macromolecular Crystallography

Other Facilities: no