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Two-stage directed self-assembly of a cyclic [3]catenane

DOI: 10.1038/nchem.2205 DOI Help

Authors: Christopher Wood (University of Cambridge) , Tanya Ronson (University of Cambridge) , Ana M. Belenguer (University of Cambridge) , Julian Holstein (Global Phasing Ltd.) , Jonathan R. Nitschke (University of Cambridge)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Nature Chemistry , VOL 7 (4) , PAGES 354 - 358

State: Published (Approved)
Published: April 2015
Diamond Proposal Number(s): 7984 , 8464

Abstract: Interlocked molecules possess properties and functions that depend upon their intricate connectivity. In addition to the topologically trivial rotaxanes, whose structures may be captured by a planar graph, the topologically non-trivial knots and catenanes represent some of chemistry's most challenging synthetic targets because of the three-dimensional assembly necessary for their construction. Here we report the synthesis of a cyclic [3]catenane, which consists of three mutually interpenetrating rings, via an unusual synthetic route. Five distinct building blocks self-assemble into a heteroleptic triangular framework composed of two joined FeII3L3 circular helicates. Subcomponent exchange then enables specific points in the framework to be linked together to generate the cyclic [3]catenane product. Our method represents an advance both in the intricacy of the metal-templated self-assembly procedure and in the use of selective imine exchange to generate a topologically complex product.

Subject Areas: Chemistry

Instruments: I19-Small Molecule Single Crystal Diffraction

Added On: 25/03/2015 17:34

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