Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases--key enzymes in bacterial and fungal mannoprotein metabolism

DOI: 10.1002/anie.201410502
PMID: 25772148

Authors: Andrew J. Thompson (University of York) , Gaetano Speciale (University of Melbourne) , Javier Iglesias-Fernández (Universitat de Barcelona) , Zalihe Hakki (University of York) , Tyson Belz (University of Melbourne) , Alan Cartmell (University of Melbourne) , Richard J. Spears (University of York) , Emily Chandler (University of York) , Max J. Temple (Newcastle University) , Judith Stepper (University of York) , Harry J. Gilbert (Newcastle University) , Carme Rovira (Universitat de Barcelona) , Spencer J. Williams (University of Melbourne) , Gideon J. Davies (University of York)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie International Edition

State: Published (Approved)
Published: March 2015
Diamond Proposal Number(s): 7864 , 9948

Abstract: carbohydrates;computational chemistry;conformational analysis;enzymatic mechanisms;glycosidase inhibitors

Journal Keywords: Carbohydrates; Computational Chemistry; Conformational Analysis; Enzymatic Mechanisms; Glycosidase Inhibitors

Diamond Keywords: Fungi

Subject Areas: Biology and Bio-materials, Chemistry, Medicine


Instruments: I03-Macromolecular Crystallography , I04-1-Macromolecular Crystallography (fixed wavelength)

Added On: 27/03/2015 11:49

Discipline Tags:

Pathogens Health & Wellbeing Biochemistry Chemistry Structural biology Drug Discovery Life Sciences & Biotech

Technical Tags:

Diffraction Macromolecular Crystallography (MX)