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Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum

DOI: 10.1016/j.neuron.2014.12.020 DOI Help
PMID: 25611509 PMID Help

Authors: Wataru Kakegawa (Keio University School of Medicine) , Nikolaos Mitakidis (Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford) , Eriko Miura (Keio University School of Medicine) , Manabu Abe (Japan Science and Technology Agency (JST)) , Keiko Matsuda (Keio University School of Medicine) , Yukari h. Takeo (Keio University School of Medicine) , Kazuhisa Kohda (Keio University School of Medicine) , Junko Motohashi (Keio University School of Medicine) , Akiyo Takahashi (Keio University School of Medicine) , Soichi Nagao (RIKEN Brain Science Institute) , Shin-ichi Muramatsu (Jichi Medical University) , Masahiko Watanabe (Japan Science and Technology Agency (JST)) , Kenji Sakimura (Japan Science and Technology Agency (JST)) , Alexandru Aricescu (Division of Structural Biology, University of Oxford) , Michisuke Yuzaki (Keio University School of Medicine)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Neuron , VOL 85 (2) , PAGES 316 - 329

State: Published (Approved)
Published: January 2015
Diamond Proposal Number(s): 10627

Open Access Open Access

Abstract: Kakegawa et al. demonstrate that C1ql1 provided by climbing fibers (CFs) serves as a new antegrade signal to determine and maintain a single-winner CF throughout development and adulthood by binding to its postsynaptic receptor Bai3 in cerebellar Purkinje cells.

Subject Areas: Biology and Bio-materials, Medicine

Instruments: I04-Macromolecular Crystallography

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