Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum

DOI: 10.1016/j.neuron.2014.12.020
PMID: 25611509

Authors: Wataru Kakegawa (Keio University School of Medicine) , Nikolaos Mitakidis (Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford) , Eriko Miura (Keio University School of Medicine) , Manabu Abe (Japan Science and Technology Agency (JST)) , Keiko Matsuda (Keio University School of Medicine) , Yukari h. Takeo (Keio University School of Medicine) , Kazuhisa Kohda (Keio University School of Medicine) , Junko Motohashi (Keio University School of Medicine) , Akiyo Takahashi (Keio University School of Medicine) , Soichi Nagao (RIKEN Brain Science Institute) , Shin-Ichi Muramatsu (Jichi Medical University) , Masahiko Watanabe (Japan Science and Technology Agency (JST)) , Kenji Sakimura (Japan Science and Technology Agency (JST)) , Alexandru Aricescu (Division of Structural Biology, University of Oxford) , Michisuke Yuzaki (Keio University School of Medicine)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Neuron , VOL 85 (2) , PAGES 316 - 329

State: Published (Approved)
Published: January 2015
Diamond Proposal Number(s): 10627

Abstract: Neuronal networks are dynamically modified by selective synapse pruning during development and adulthood. However, how certain connections win the competition with others and are subsequently maintained is not fully understood. Here, we show that C1ql1, a member of the C1q family of proteins, is provided by climbing fibers (CFs) and serves as a crucial anterograde signal to determine and maintain the single-winner CF in the mouse cerebellum throughout development and adulthood. C1ql1 specifically binds to the brain-specific angiogenesis inhibitor 3 (Bai3), which is a member of the cell-adhesion G-protein-coupled receptor family and expressed on postsynaptic Purkinje cells. C1ql1-Bai3 signaling is required for motor learning but not for gross motor performance or coordination. Because related family members of C1ql1 and Bai3 are expressed in various brain regions, the mechanism described here likely applies to synapse formation, maintenance, and function in multiple neuronal circuits essential for important brain functions.

Subject Areas: Biology and Bio-materials


Instruments: I04-Macromolecular Crystallography

Added On: 27/03/2015 14:05

Discipline Tags:

Health & Wellbeing Neurology Structural biology Life Sciences & Biotech

Technical Tags:

Diffraction Macromolecular Crystallography (MX)