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A novel experimental approach to investigate radiolysis processes in liquid samples using collimated radiation sources

DOI: 10.1063/1.4914054 DOI Help

Authors: Christopher Polin (Queen's University of Belfast) , Nathan Wardlow (Queen's University of Belfast) , Harold Mcquaid (Queen's University of Belfast) , Philip Orr (Queen's University of Belfast) , Balder Villagomez (Queen's University of Belfast) , Catarina Figueira (Queen's University of Belfast) , Grace Alexander (Queen's University of Belfast) , Shajeth Srigengan (University of Manchester) , Emilie Brun (Paris-Sud University) , Manon Gilles (Paris-Sud University) , Cecile Sicard (Paris-Sud University) , Fred Currell (Queen's University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Review Of Scientific Instruments , VOL 86 (3) , PAGES 853-858

State: Published (Approved)
Published: March 2015
Diamond Proposal Number(s): 8062 , 8063 , 8481 , 8482 , 9104 , 9501 , 9502 , 10228 , 11529

Abstract: Here is detailed a novel and low-cost experimental method for high-throughput automated fluid sample irradiation. The sample is delivered via syringe pump to a nozzle, where it is expressed in the form of a hanging droplet into the path of a beam of ionising radiation. The dose delivery is controlled by an upstream lead shutter, which allows the beam to reach the droplet for a user defined period of time. The droplet is then further expressed after irradiation until it falls into one well of a standard microplate. The entire system is automated and can be operated remotely using software designed in-house, allowing for use in environments deemed unsafe for the user (synchrotron beamlines, for example). Depending on the number of wells in the microplate, several droplets can be irradiated before any human interaction is necessary, and the user may choose up to 10 samples per microplate using an array of identical syringe pumps, the design of which is described here. The nozzles consistently produce droplets of 25.1 ± 0.5 ul.

Journal Keywords: Sample handling; Therapeutics; Radiolysis processes; Dosimeters; UV-visible spectroscopy; Diseases and conditions; Polymers; Radiation therapy; Nanoparticles; Synchrotrons

Subject Areas: Physics, Technique Development, Medicine

Instruments: B16-Test Beamline , I15-Extreme Conditions

Added On: 08/04/2015 13:39

Discipline Tags:

Physics Technique Development - Physics

Technical Tags: