The importance of loop length on the stability of i-motif structures

DOI: 10.1039/C4CC07279K
PMID: 25686374

Authors: Sarah Gurung (University of Reading; Diamond Light Source) , Christine Schwarz (University of Reading) , James P. Hall (University of Reading; Diamond Light Source) , Christine J. Cardin (University of Reading) , John A. Brazier (University of Reading)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications , VOL 51 (26) , PAGES 5630 - 5632

State: Published (Approved)
Published: January 2015
Diamond Proposal Number(s): 9684 , 10076

Abstract: Using UV and srCD spectroscopy it is found that loop length within the i-motif structure is important for both thermal and pH stability, but in contrast to previous statements, it is the shorter loops that exhibit the highest stability.

Subject Areas: Chemistry, Biology and Bio-materials


Instruments: B23-Circular Dichroism

Added On: 13/04/2015 10:44

Discipline Tags:

Biochemistry Chemistry Life Sciences & Biotech

Technical Tags:

Spectroscopy Circular Dichroism (CD)