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X-ray study of human dental tissues affected by erythroblastosis fetalis

DOI: 10.1177/0022034515580987 DOI Help
PMID: 25858817 PMID Help

Authors: Tan Sui (University of Oxford) , Siqi Ying (University of Oxford) , Alexander Korsunsky (University of Oxford) , G. Landini (University of Birmingham)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Dental Research

State: Published (Approved)
Published: April 2015
Diamond Proposal Number(s): 9318 , 5038

Abstract: Numerous diseases are known to cause microstructural alteration of dental tissues structure. One type in particular is associated with neonatal jaundice and circulation of bilirubin in blood at high concentration due to increased hemolysis in conditions such as erythroblastosis fetalis, septicemia, biliary atresia, and other causes of hyperbilirubinemia. In those conditions, the products of the catabolism of hemoglobin end up deposited in various tissues, including teeth, where they can present clinically as visibly stained brown/green teeth. There is almost no information on the nature or extent of the structural changes taking place in these conditions. Here, advanced nondestructive wide-angle synchrotron X-ray scattering techniques combined with scanning microscopy methods were used to investigate for the first time the ultrastructure of the dental hard tissues in an archival case of intrinsically pigmented green teeth. Despite no obvious elemental variation across the pigmented tissue region, the high-resolution crystallographic properties probed by wide-angle synchrotron X-ray scattering revealed an ultrastructural variation (orientation, particle size, and lattice parameter of hydroxyapatite crystallites) associated with a pigmentation line in dentine and with a distinct neonatal line in enamel.

Journal Keywords: bilirubin; tooth; pigments; dental enamel; dentine; neonatal jaundice

Subject Areas: Medicine, Biology and Bio-materials

Instruments: B16-Test Beamline

Added On: 18/04/2015 07:59

Discipline Tags:

Dentistry Health & Wellbeing Life Sciences & Biotech

Technical Tags: