Publication
Age-related increased R2 and R2* correlates with increased brain iron in a normal ageing mouse model
Authors:
Thomas
Walker
(Kings College London)
,
Christos
Michaelides
(King's College London)
,
Harry
Parkes
(CR-UK)
,
William
Crum
(Kings College London)
,
Amy
Herlihy
(Agilent technologies)
,
Tina
Geraki
(Diamond Light Source)
,
Po-wah
So
(King's College London)
Co-authored by industrial partner:
Yes
Type:
Conference Paper
Conference:
ISMRM 23rd Annual Meeting & Exhibition
Peer Reviewed:
No
State:
Published (Approved)
Published:
June 2015
Diamond Proposal Number(s):
10615
Abstract: Brain iron accumulation with ageing may play a role in senescent processes, with age-related increases in basal ganglia R2 and R2* observed in man and associated with increased iron. Here, we show similar increases in R2 and R2* in the basal ganglia of ageing C57BL/6J mice. Quantitatively measured increased iron by synchrotron radiation X-ray fluorescence elemental iron mapping suggests the increased R2 and R2* values may indeed arise from higher iron concentrations. Thus, iron dyshomeostasis may play a role in ageing and MR relaxometry may be used to monitor these ageing processes.
Subject Areas:
Biology and Bio-materials,
Medicine
Instruments:
I18-Microfocus Spectroscopy
Discipline Tags:
Technical Tags: