Age-related increased R2 and R2* correlates with increased brain iron in a normal ageing mouse model

Authors: Thomas Walker (Kings College London) , Christos Michaelides (King's College London) , Harry Parkes (CR-UK) , William Crum (Kings College London) , Amy Herlihy (Agilent technologies) , Tina Geraki (Diamond Light Source) , Po-wah So (King's College London)
Co-authored by industrial partner: Yes

Type: Conference Paper
Conference: ISMRM 23rd Annual Meeting & Exhibition
Peer Reviewed: No

State: Published (Approved)
Published: June 2015
Diamond Proposal Number(s): 10615

Abstract: Brain iron accumulation with ageing may play a role in senescent processes, with age-related increases in basal ganglia R2 and R2* observed in man and associated with increased iron. Here, we show similar increases in R2 and R2* in the basal ganglia of ageing C57BL/6J mice. Quantitatively measured increased iron by synchrotron radiation X-ray fluorescence elemental iron mapping suggests the increased R2 and R2* values may indeed arise from higher iron concentrations. Thus, iron dyshomeostasis may play a role in ageing and MR relaxometry may be used to monitor these ageing processes.

Subject Areas: Biology and Bio-materials, Medicine

Instruments: I18-Microfocus Spectroscopy