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Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

DOI: 10.1042/BJ20110002 DOI Help
PMID: 21410435 PMID Help

Authors: Marcio v. b. Dias (University of Cambridge) , William c. Snee (Texas A&M University) , Karen m. Bromfield (University of Cambridge) , Richard j. Payne (University of Cambridge) , Satheesh k. Palaninathan (Texas A&M University) , Alessio Ciulli (University of Cambridge) , Nigel i. Howard (University of Cambridge) , Chris Abell (University of Cambridge) , James c. Sacchettini (Texas A&M University) , Tom l. Blundell (University of Cambridge)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Biochemical Journal , VOL 436 (3) , PAGES 729 - 739

State: Published (Approved)
Published: June 2011

Abstract: Key words: 3-dehydroquinate dehydratase (dehydroquinase), drug discovery, inhibitor design, Mycobacterium tuberculosis, shikimate pathway, transition state analogue.

Journal Keywords: Catalytic; Crystallography ; X-Ray ; Drug; Enzyme; Hydro-Lyases ; Isonicotinic; Models ; Molecular ; Mycobacterium; Quinic Acid

Subject Areas: Biology and Bio-materials

Instruments: I04-Macromolecular Crystallography

Other Facilities: beamline 19-ID and 23-ID of the Advanced Photon Source, Argonne ESRF SLS

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