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Self-Assembly Pathway of Peptide Nanotubes Formed by a Glutamatic Acid-Based Bolaamphiphile

DOI: 10.1039/C5CC03640B DOI Help

Authors: Emerson Da Silva (University of Reading) , Wendel Alves (University of Reading) , Valeria Castelletto (University of Reading) , Mehedi Reza (Aalto University School of Science) , Janne Ruokolainen (Aalto University School of Science) , Rohanah Hussain (Diamond Light Source) , Ian Hamley (University Of Reading)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications

State: Published (Approved)
Published: June 2015
Diamond Proposal Number(s): 10083

Abstract: The self-assembly of peptide-nanotubes formed by an L-glutamic acid-based bolaamphiphile is shown to proceed via a remarkable mechanism where the peptide conformation changes from beta-sheet to unordered. The kinetics of this process are elucidated via X-ray scattering and UV circular dichroism methods. The reverse transition from “unordered” to beta-sheet structures is triggered by UV radiation.

Subject Areas: Biology and Bio-materials


Instruments: B23-Circular Dichroism

Other Facilities: ESRF; MaxLab II

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