Age-­related changes in MRI relaxometry in a mouse model of normal ageing

Authors: Thomas Walker (Kings College London) , Christos Michaelides (King's College London) , Harry Parkes (Institute of Cancer Research) , W Crum (King’s College London) , Amy H Herlihy (Agilent Technologies) , Po-wah So (King’s College London)
Co-authored by industrial partner: No

Type: Poster

State: Published (Approved)
Published: November 2013

Open Access Open Access

Abstract: Brain  senescence  is  a  complex  process  affecting  a  multitude  of  molecular  and   structural  mechanisms  culminating  in  perturbed  cognitive  and  motor  abilities.     •Dysfunctional  mitochondria  driven  by  oxidative  stress  mechanisms  and  potential   increases  in  iron  have  been  postulated  as  potential  key  mediators  of  senescent   mechanisms.     •Magnetic  resonance  imaging  relaxometry  is  a  well-­documented  iron-­sensitive   technique  that  has  been  used  to  demonstrate  elevations  in  brain  iron  during   ageing,  most  notably  in  the  basal  ganglia.     •To  date,  no  study  has  demonstrated  age-­related  changes  in  MR  relaxometry  with   direct  and  quantitative  measures  of  brain  iron  levels.

Subject Areas: Biology and Bio-materials

Instruments: I18-Microfocus Spectroscopy