A new polymorph of metacetamol

DOI: 10.1039/C5CE00910C

Authors: Lindsay Mcgregor (The University of Edinburgh) , Denis A. Rychkov (Novosibirsk State University) , Paul Coster (University of Edinburgh) , Sarah Day (Diamond Light Source) , Valeri A Drebushchak (Novosibirsk State University) , Andrey F. Achkasov (Novosibirsk State University) , Gary S. Nichol (The University of Edinburgh) , Elena Boldyreva (Novosibirsk State University) , Colin Pulham (University of Edinburgh)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Crystengcomm

State: Published (Approved)
Published: July 2015
Diamond Proposal Number(s): 9918

Abstract: Metacetamol is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. Due to the importance of the well-known polymorphism of paracetamol, an investigation of the polymorphism of metacetamol was successfully undertaken. A new polymorph of metacetamol has been discovered and extensively characterised using a variety of analytical techniques (IR- and Raman spectroscopy, UV-visible optical spectroscopy, X-ray powder and single-crystal diffraction, TGA and DSC). A procedure for the reliable and reproducible preparation of the new polymorph is described. Its properties and crystal structure are compared with those of the previously known polymorph, as well as with those of paracetamol.

Subject Areas: Chemistry, Medicine


Instruments: I11-High Resolution Powder Diffraction

Added On: 22/07/2015 10:00

Discipline Tags:

Health & Wellbeing Chemistry Organic Chemistry Drug Discovery Life Sciences & Biotech

Technical Tags:

Diffraction X-ray Powder Diffraction