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Glaucoma-related Changes in the Mechanical Properties and Collagen Micro-architecture of the Human Sclera

DOI: 10.1371/journal.pone.0131396 DOI Help
PMID: 26161963 PMID Help

Authors: Baptiste Coudrillier (Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta) , Jacek Pijanka (Cardiff University) , Joan L. Jefferys (Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore) , Adhiraj Goel (Department of Mechanical Engineering, Johns Hopkins University, Baltimore) , Harry A. Quigley (Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore) , Craig Boote (University of Cardiff) , Thao Nguyen (Department of Mechanical Engineering, Johns Hopkins University, Baltimore) , Ted S Acott
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Plos One , VOL 10 (7)

State: Published (Approved)
Published: July 2015

Open Access Open Access

Abstract: The biomechanical behavior of the sclera determines the level of mechanical insult from intraocular pressure to the axons and tissues of the optic nerve head, as is of interest in glaucoma. In this study, we measure the collagen fiber structure and the strain response, and estimate the material properties of glaucomatous and normal human donor scleras.

Journal Keywords: Glaucoma; Collagens; Diabetes Mellitus; Material Properties

Subject Areas: Biology and Bio-materials, Materials


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Added On: 20/08/2015 14:21

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