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Regioswitchable Palladium-Catalyzed Decarboxylative Coupling of 1,3-Dicarbonyl Compounds

DOI: 10.1021/acs.orglett.5b01979 DOI Help

Authors: Miles Kenny (Lancaster University) , Jeppe Christensen (University of Southampton) , Simon Coles (University of Southampton) , Vilius Franckevičius (Lancaster University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Organic Letters , VOL 17 (15) , PAGES 3926 - 3929

State: Published (Approved)
Published: August 2015
Diamond Proposal Number(s): 8521 , 11238

Abstract: A palladium-catalyzed chemo- and regioselective coupling of 1,3-dicarbonyl compounds via an allylic linker has been developed. This reaction, which displays broad substrate scope, forms two C–C bonds and installs two all-carbon quaternary centers. The regioselectivity of the reaction can be predictably controlled by utilizing an enol carbonate of one of the coupling partners.

Subject Areas: Chemistry

Instruments: I19-Small Molecule Single Crystal Diffraction