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Barium titanate nanoparticles for biomarker applications

DOI: 10.1088/1742-6596/644/1/012037 DOI Help

Authors: O. Matar (University of Leeds) , O. M. Posada (University of Leeds) , N. S. Hondow (University of Leeds) , C. Walti (University of Leeds) , M. Saunders (The University of Western Australia) , C. A. Murray (Diamond Light Source) , R. M. D. Brydson (University of Leeds) , S. J. Milne (University of Leeds) , A. P. Brown (University of Leeds)
Co-authored by industrial partner: No

Type: Conference Paper
Conference: Electron Microscopy and Analysis Group Conference (EMAG2015)
Peer Reviewed: No

State: Published (Approved)
Published: October 2015

Open Access Open Access

Abstract: A tetragonal crystal structure is required for barium titanate nanoparticles to exhibit the nonlinear optical effect of second harmonic light generation (SHG) for use as a biomarker when illuminated by a near-infrared source. Here we use synchrotron XRD to elucidate the tetragonal phase of commercially purchased tetragonal, cubic and hydrothermally prepared barium titanate (BaTiO3) nanoparticles by peak fitting with reference patterns. The local phase of individual nanoparticles is determined by STEM electron energy loss spectroscopy (EELS), measuring the core-loss O K-edge and the Ti L3-edge energy separation of the t2g, eg peaks. The results show a change in energy separation between the t2g and eg peak from the surface and core of the particles, suggesting an intraparticle phase mixture of the barium titanate nanoparticles. HAADF-STEM and bright field TEM-EDX show cellular uptake of the hydrothermally prepared BaTiO3 nanoparticles, highlighting the potential for application as biomarkers.

Subject Areas: Physics, Materials

Instruments: I11-High Resolution Powder Diffraction

Added On: 18/10/2015 18:52


Discipline Tags:

Physics Materials Science Nanoscience/Nanotechnology

Technical Tags:

Diffraction X-ray Powder Diffraction