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1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex

DOI: 10.1107/S2053230X1501643X DOI Help
PMID: 26457524 PMID Help

Authors: Eugene Valkov (MRC Laboratory of Molecular Biology, Cambridge, U.K.) , Murray Stewart (MRC Laboratory of Molecular Biology, Cambridge, U.K.)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Acta Crystallographica Section F Structural Biology Communications , VOL 71 , PAGES 1318 - 1321

State: Published (Approved)
Published: October 2015

Open Access Open Access

Abstract: The 1.25 Å resolution H32:R crystal structure of a 20 nt ribonucleotide that binds to the TREX-2 complex with high affinity shows a double-stranded RNA duplex arranged along a crystallographic 31 axis in which the antiparallel chains overlap by 18 nucleotides and are related by a crystallographic twofold axis. The duplex shows C–A, U–U and C–C noncanonical base pairings together with canonical Watson–Crick A–U and G–C pairs and a G–U wobble.

Journal Keywords: Rna; Noncanonical Base Pair

Subject Areas: Biology and Bio-materials

Instruments: I04-1-Macromolecular Crystallography (fixed wavelength)

Added On: 19/10/2015 19:43

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