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A simple model to quantify radiolytic production following electron emission from heavy-atom nanoparticles irradiated in liquid suspensions

DOI: 10.1667/RR14059.1 DOI Help
PMID: 26488757 PMID Help

Authors: Nathan Wardlow (Queen's University of Belfast) , Chris Polin (Queen's University of Belfast) , Balder Villagomez-Bernabe (Queen's University of Belfast) , Fred Currell (Queen's University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Radiation Research , VOL 184 (5) , PAGES 518-532

State: Published (Approved)
Published: October 2015
Diamond Proposal Number(s): 8481 , 8482 , 9104

Open Access Open Access

Abstract: We present a simple model for a component of the radiolytic production of any chemical species due to electron emission from irradiated nanoparticles (NPs) in a liquid environment, provided the expression for the G-Value for product formation is known and is reasonably well characterized by a linear dependence on beam energy. This model takes nanoparticle size, composition, density and a number of other readily available parameters (such as X-ray and electron attenuation data) as inputs and hence allows for the ready determination of this contribution. Several approximations are used – as such this model provides an upper limit to the yield of chemical species due to electron emission, rather than a distinct value – this upper limit is compared with experimental results. After the general model is developed we present details of its application to the generation of HO• through irradiation of gold nanoparticles (AuNPs), a potentially important process in nanoparticle-based enhancement of radiotherapy. This model has been constructed with the intention of making it accessible to other researchers who wish to estimate chemical yields through this process, and is shown to be applicable to NPs of single elements and mixtures. The model can be applied without the need to develop additional skills (such as using a Monte-Carlo toolkit), providing a fast and straightforward method of estimating chemical yields. A simple framework for determining the HO• yield for different NP sizes at constant NP concentration and initial photon energy is also presented.

Journal Keywords: Radiolysis nanoparticle

Subject Areas: Chemistry, Physics, Medicine

Instruments: B16-Test Beamline , I15-Extreme Conditions

Added On: 13/11/2015 09:58


Discipline Tags:

Physics Physical Chemistry Chemistry Materials Science Nanoscience/Nanotechnology Life Sciences & Biotech

Technical Tags:

Diffraction Spectroscopy X-ray Absorption Spectroscopy (XAS)