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Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody

DOI: 10.1128/JVI.02105-15 DOI Help
PMID: 26468526 PMID Help

Authors: Ki Joon Cho (Medical Biotechnology Center, VIB) , Bert Schepens (Medical Biotechnology Center, VIB) , Kristof Moonens (Structural Biology Research Center, VIB) , Lei Deng (Medical Biotechnology Center, VIB) , Walter Fiers (Medical Biotechnology Center, VIB) , Han Remaut (Structural Biology Research Center, VIB) , Xavier Saelens (Medical Biotechnology Center, VIB)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Virology

State: Published (Approved)
Published: October 2015

Abstract: We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino-terminus of M2. M2e stretches out into the antibody binding site to form an N-terminal β-turn near the bottom of the paratope. This M2e folding differs significantly from M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.

Subject Areas: Biology and Bio-materials

Instruments: I24-Microfocus Macromolecular Crystallography