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Structural insights into how 5-hydroxymethylation influences transcription factor binding

DOI: 10.1039/C3CC48151D DOI Help
PMID: 24287551 PMID Help

Authors: Lukas Lercher (Chemistry Research Laboratory, Oxford) , Michael A. Mcdonough (Chemistry Research Laboratory, Oxford) , Afaf H. El-sagheer (Chemistry Research Laboratory, Oxford) , Armin Thalhammer (Chemistry Research Laboratory, Oxford) , Skirmantas Kriaucionis (Chemistry Research Laboratory, Oxford) , Tom Brown (Chemistry Research Laboratory, Oxford) , Christopher J. Schofield (Chemistry Research Laboratory, Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications , VOL 50 (15) , PAGES 1794 - 1796

State: Published (Approved)
Published: November 2013

Abstract: Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson–Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.

Subject Areas: Biology and Bio-materials


Instruments: I04-1-Macromolecular Crystallography (fixed wavelength)