Endochondral growth defect and deployment of transient chondrocyte behaviours underlie osteoarthritis onset in a natural murine model

DOI: 10.1002/art.39508
PMID: 26605758

Authors: K. A. Staines (Royal Veterinary College) , K. Madi (Research Complex at Harwell) , S. M. Mirczuk (The Royal Veterinary College) , S. Parker (The Royal Veterinary College) , A. Burleigh (The Royal Veterinary College) , B. Poulet (University Collge London) , M. Hopkinson (The Royal Veterinary College) , A. J. Bodey (Diamond Light Source) , R. C. Fowkes (The Royal Veterinary College) , C. Farquharson (University of Edinburgh) , P. D. Lee (University of Manchester) , A. A. Pitsillides (The Royal Veterinary College)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Arthritis & Rheumatology

State: Published (Approved)
Published: November 2015

Abstract: To explore whether aberrant transient chondrocyte behaviours occur in STR/Ort mouse joints (spontaneously osteoarthritis) and whether this is attributable to an endochondral growth defect.

Journal Keywords: Osteoarthritis; Growth Plate; Mineralisation; Chondrocyte; Str; Ort

Diamond Keywords: Osteoarthritis

Subject Areas: Biology and Bio-materials


Instruments: I13-2-Diamond Manchester Imaging

Added On: 05/12/2015 19:45

Documents:
Arthritis Rheumatology - 2015 - Staines - Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors.pdf

Discipline Tags:

Health & Wellbeing Life Sciences & Biotech

Technical Tags:

Imaging Tomography