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Phase-contrast Micro-computed Tomography Measurements of the Intraocular Pressure-induced Deformation of the Porcine Lamina Cribrosa

DOI: 10.1109/TMI.2015.2504440 DOI Help

Authors: Baptiste Coudrillier (Johns Hopkins University) , Diogo Geraldes (Imperial College London) , Nghia Vo (Diamond Light Source) , Robert Atwood (Diamond Light Source) , Christina Reinhard (Diamond Light Source) , Ian Campbell (Georgia Institute of Technology and Emory University,) , Yazdan Raji (Georgia Institute of Technology and Emory University,) , Julie Albon (Cardiff University) , Richard Abel (Imperial College London) , Ross Ethier (Georgia Institute of Technology and Emory University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Ieee Transactions On Medical Imaging , VOL PP (99) , PAGES PP (99)

State: Published (Approved)
Published: November 2015
Diamond Proposal Number(s): 8491 , 9825 , 11407

Abstract: The lamina cribrosa (LC) is a complex mesh-like tissue in the posterior eye. Its biomechanical environment is thought to play a major role in glaucoma, the second most common cause of blindness. Due to its small size and relative inaccessibility, highresolution measurements of LC deformation, important in characterizing LC biomechanics, are challenging. Here we present a novel noninvasive imaging method, which enables measurement of the three-dimensional deformation of the LC caused by acute elevation of intraocular pressure (IOP). Posterior segments of porcine eyes were imaged using synchrotron radiation phase contrast micro-computed tomography (PC CT) at IOPs between 6 and 37mmHg. The complex trabecular architecture of the LC was reconstructed with an isotropic spatial resolution of 3.2 m. Scans acquired at different IOPs were analyzed with digital volume correlation (DVC) to compute full-field deformation within the LC. IOP elevation caused substantial tensile, shearing and compressive deformation within the LC, with maximum tensile strains at 30mmHg averaging 5.5%, and compressive strains reaching 20%. We conclude that PC CT provides a novel high-resolution method for imaging the LC, and when combined with DVC, allows for full-field 3D measurement of ex vivo LC biomechanics at high spatial resolution.

Journal Keywords: X-Ray Tomography; Strain Measurements; Biomechanics

Subject Areas: Medicine, Biology and Bio-materials

Instruments: I12-JEEP: Joint Engineering, Environmental and Processing

Added On: 10/12/2015 11:46

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