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Designed Enclosure Enables Guest Binding Within the 4200 Å

DOI: 10.1002/ange.201501892 DOI Help

Authors: William Ramsay (University of Cambridge) , Filip T. Szczypiński (University of Cambridge) , Haim Weissman (University of Cambridge) , Tanya Ronson (University of Cambridge) , Maarten M. J. Smulders (University of Cambridge) , Boris Rybtchinski (University of Cambridge) , Jonathan R. Nitschke (University of Cambridge)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie , VOL 127 , PAGES 5728 - 5732

State: Published (Approved)
Published: May 2015
Diamond Proposal Number(s): 7569 , 8464

Abstract: Metal-organic self-assembly has proven to be of great use in constructing structures of increasing size and intricacy, but the largest assemblies lack the functions associated with the ability to bind guests. Here we demonstrate the self-assembly of two simple organic molecules with Cd(II) and Pt(II) into a giant heterometallic supramolecular cube which is capable of binding a variety of mono- and dianionic guests within an enclosed cavity greater than 4200 Å(3) . Its structure was established by X-ray crystallography and cryogenic transmission electron microscopy. This cube is the largest discrete abiological assembly that has been observed to bind guests in solution; cavity enclosure and coulombic effects appear to be crucial drivers of host-guest chemistry at this scale. The degree of cavity occupancy, however, appears less important: the largest guest studied, bound the most weakly, occupying only 11 % of the host cavity.

Journal Keywords: electron microscopy; host-guest chemistry; integrative self-sorting; metal-organic cages; supramolecular chemistry

Subject Areas: Chemistry

Instruments: I19-Small Molecule Single Crystal Diffraction

Added On: 12/01/2016 13:38

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