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Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex

DOI: 10.1002/anie.201502608 DOI Help
PMID: 26096623 PMID Help

Authors: Paraic M. Keane (University of Reading) , Fergus E. Poynton (Trinity College) , James P. Hall (Diamond Light Source; University of Reading) , Igor V. Sazanovich (STFC Rutherford Appleton Laboratory) , Michael Towrie (STFC Rutherford Appleton Laboratory) , Thorfinnur Gunnlaugsson (Trinity College) , Susan J. Quinn (University College Dublin) , Christine J. Cardin (University of Reading) , John M. Kelly (Trinity College)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie International Edition , VOL 54 (29) , PAGES 8364 - 8368

State: Published (Approved)
Published: July 2015

Open Access Open Access

Abstract: Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ-[Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using pico/nanosecond transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ versus 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides

Journal Keywords: Dna; Electron Transfer; Photooxidation; Ruthenium; Time-Resolved Spectroscopy

Subject Areas: Chemistry

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Added On: 09/02/2016 16:36

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