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Trapping Reactive Intermediates by Mechanochemistry: Elusive Aryl

DOI: 10.1002/ange.201502026 DOI Help

Authors: Vjekoslav Štrukil (McGill University) , Davor Gracin (Ruđer Bošković Institute) , Oxana Magdysyuk (Diamond Light Source; Max Planck Institute for Solid State Research, Stuttgart;) , Robert Dinnebier (Max Planck Institute for Solid State Research, Stuttgart) , Tomislav Friscic (McGill University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie , VOL 127 (29) , PAGES 8560 - 8563

State: Published (Approved)
Published: July 2015

Abstract: Monitoring of mechanochemical thiocarbamoylation by in situ Raman spectroscopy revealed the formation of aryl N-thiocarbamoylbenzotriazoles, reactive intermediates deemed unisolable in solution. The first-time isolation and structural characterization of these elusive molecules demonstrates the ability of mechanochemistry to access otherwise unobtainable intermediates and offers a new range of masked isothiocyanate reagents.

Journal Keywords: Mechanochemie;Reaktive Zwischenstufen;Thiocarbamoylierungen;Thioharnstoff

Subject Areas: Chemistry

Facility: CLS