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The VIZIER project: Preparedness against pathogenic RNA viruses

DOI: 10.1016/j.antiviral.2007.10.013 DOI Help

Authors: B. Coutard (Architecture et Fonction des Macromolécules Biologiques, CNRS, and Universités d'Aix-Marseille I et II) , A E Gorbalenya (Leiden University Medical Center) , E J Snijder (Leiden University Medical Center) , A M Leontovich (Moscow State University) , A. Poupon (Structural Genomics Laboratory, IBBMC, CNRS UMR) , X. De Lamballerie (Unit´e des Virus Emergents) , R. Charrel (Unit´e des Virus Emergents) , E A Gould (Center for Ecology and Hydrology-Oxford) , S. Gunther (Bernhard Nocht Institute for Tropical Medicine) , H. Norder (V, Swedish Institute for Infectious Disease Control) , B. Klempa (Slovak Academy of Sciences) , H. Bourhy (Institut Pasteur) , J. Rohayem (Institut f ¨ur Virologie, Medizinische Fakult ¨at Carl Gustav Carus) , E. L’hermite (BioXtal) , P. Nordlund (Architecture et Fonction des Macromolécules Biologiques, CNRS, and Universités d'Aix-Marseille I et Il) , Dave Stuart (Diamond Light Source) , Ray Owens (University of Oxford) , Jonathan Grimes (Division of Structural Biology, University of Oxford) , P.a. Tucker (European Molecular Biology Laboratory) , M. Bolognesi (CNR-INFM, University of Milano) , A. Mattevi (University of Pavia) , M. Coll (Institut de Recerca Biom`edica and Institut de Biologia Molecular de Barcelona) , T.a. Jones (Uppsala University) , J. Åqvist (Uppsala University) , T. Unge (Uppsala University) , R. Hilgenfeld (University of Lubeck) , G. Bricogne (Global Phasing, Sheraton House) , J. Neyts (Rega Institute for Medical Research) , P. La Colla (University of Cagliari) , G. Puerstinger (Universitat Innsbruck) , J P Gonzalez (IRD-R178 Mahidol University) , E. Leroy (IRD-R178 Mahidol University) , C. Cambillau (Architecture et Fonction des Macromol´ecules Biologiques, CNRS, and Universit´es d’Aix-Marseille I et II) , J.l. Romette (Architecture et Fonction des Macromol´ecules Biologiques, CNRS, and Universit´es d’Aix-Marseille I et II) , B. Canard (Architecture et Fonction des Macromol´ecules Biologiques, CNRS, and Universit´es d’Aix-Marseille I et II)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Antiviral Research , VOL 78 (1) , PAGES 37 - 46

State: Published (Approved)
Published: April 2008

Abstract: Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules

Journal Keywords: RNA virus; Genomics; Crystal structure; Replicase; Antivirals; Drug-design

Subject Areas: Medicine


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