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Inhibition of influenza H5N1 invasion by modified heparin derivatives

DOI: 10.1039/C4MD00516C DOI Help

Authors: Mark Skidmore (University of Liverpool) , Anna Kajaste-Rudnitski (San Raffaele Telethon Institute for Gene Therapy (TIGET)) , Nicola M. Wells (University of Liverpool) , Scott Guimond (University of Liverpool) , Timothy Rudd (University of Liverpool, Diamond Light Source) , Edwin Yates (University of Liverpool) , Elisa Vicenzi (San Raffaele Scientific Institute)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Medchemcomm , VOL 6 (4) , PAGES 640 - 646

State: Published (Approved)
Published: January 2015

Abstract: Influenza remains a serious health threat, with resistance to frontline drugs becoming more common, and new treatments urgently sought. One strategy for the inhibition of the attachment of influenza to host cells is to employ chemically modified heparins, capable of effectively competing with the multivalent interactions involved. In an assay of H5N1 influenza viral invasion comprising a H5 pseudotyped HIV system, selective removal of the sulfate groups from heparin (IC50 ~22 × 10−9 g mL−1) allowed the retention of inhibitory activity in the products (IC50 ~4 × 10−9 g mL−1) while significantly reducing their anticoagulant activities. Chemically modified anionic polysaccharides offer a potential source of effective inhibitors of viral attachment, which are suitable for further optimisation.

Diamond Keywords: Influenza; Viruses

Subject Areas: Medicine, Chemistry, Biology and Bio-materials

Technical Areas:

Added On: 02/03/2016 11:14

Discipline Tags:

Pathogens Infectious Diseases Health & Wellbeing Biochemistry Chemistry Organic Chemistry Drug Discovery Life Sciences & Biotech

Technical Tags: