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Solid-Supported Lipid Multilayers under High Hydrostatic Pressure

DOI: 10.1021/acs.langmuir.5b04554 DOI Help

Authors: Benedikt Nowak (TU Dortmund University) , Michael Paulus (TU Dortmund University) , Julia Nase (TU Dortmund University) , Paul Salmen (TU Dortmund University) , Patrick Degen (TU Dortmund University) , Florian Josef Wirkert (TU Dortmund University) , Veijo Honkimaki (European Synchrotron Radiation Facility (ESRF)) , Metin Tolan (TU Dortmund University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Langmuir , VOL 32 (11) , PAGES 2638–2643

State: Published (Approved)
Published: March 2016
Diamond Proposal Number(s): 9856

Abstract: In this work, the structure of solid-supported lipid multilayers exposed to increased hydrostatic pressure was studied in situ by X-ray reflectometry at the solid−liquid interface between silicon and an aqueous buffer solution. The layers’ vertical structure was analyzed up to a maximum pressure of 4500 bar. The multilayers showed phase transitions from the fluid into different gel phases. With increasing pressure, a gradual filling of the sublayers between the hydrophilic head groups with water was observed. This process was inverted when the pressure was decreased, yielding finally smaller water layers than those in the initial state. As is commonly known, water has an abrasive effect on lipid multilayers by the formation of vesicles. We show that increasing pressure can reverse this process so that a controlled switching between multi- and bilayers is possible.

Subject Areas: Physics

Instruments: I07-Surface & interface diffraction

Other Facilities: ESRF; DELTA