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Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor
Authors:
Ming
Yang
(University of Oxford)
,
Adam P.
Hardy
(University of Oxford)
,
Rasheduzzaman
Chowdhury
(University of Oxford)
,
Nikita D.
Loik
(University of Oxford)
,
John S.
Scotti
(University of Oxford)
,
James S. O.
Mccullagh
(University of Oxford)
,
Timothy D. W.
Claridge
(University of Oxford)
,
Michael A.
Mcdonough
(University of Oxford)
,
Wei
Ge
(University of Oxford)
,
Christopher J.
Schofield
(University of Oxford)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Angewandte Chemie
, VOL 125 (6)
, PAGES 1744 - 1748
State:
Published (Approved)
Published:
February 2013
Abstract: Substrate specificity: Biochemical and crystallographic analyses reveal the hypoxia-inducible factor hydroxylase (FIH) as being promiscuous with respect to the residues that it can hydroxylate in β-position, which in addition to Asn, Asp, and His include Leu and Ser residues. The Ser substrate is oxidized to an epimeric β-geminal diol product
Journal Keywords: Ankyrins; Binding; Biocatalysis; Catalytic; Hydroxylation; Hypoxia-Inducible; Magnetic; Molecular; Peptides; Spectrometry; Mass; Matrix-Assisted; Substrate Specificity
Subject Areas:
Chemistry,
Biology and Bio-materials
Instruments:
I03-Macromolecular Crystallography
Added On:
11/03/2016 14:24
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