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YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids

DOI: 10.1038/nchembio.2023 DOI Help

Authors: Gaetano Speciale (University of Melbourne) , Yi Jin (University of York) , Gideon Davies (University of York) , Spencer J Williams (University of Melbourne) , Ethan D. Goddard-borger (The Walter and Eliza Hall Institute of Medical Research)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Nature Chemical Biology , VOL 12 , PAGES 215 - 217

State: Published (Approved)
Published: March 2016
Diamond Proposal Number(s): 9948

Abstract: Sulfoquinovose is produced by photosynthetic organisms at a rate of 1010 tons per annum and is degraded by bacteria as a source of carbon and sulfur. We have identified Escherichia coli YihQ as the first dedicated sulfoquinovosidase and the gateway enzyme to sulfoglycolytic pathways. Structural and mutagenesis studies unveiled the sequence signatures for binding the distinguishing sulfonate residue and revealed that sulfoquinovoside degradation is widespread across the tree of life.

Subject Areas: Biology and Bio-materials


Instruments: I02-Macromolecular Crystallography , I04-1-Macromolecular Crystallography (fixed wavelength) , I04-Macromolecular Crystallography

Added On: 24/03/2016 10:43

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