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Self-assembly of the cyclic lipopeptide daptomycin: spherical micelle formation does not depend on the presence of calcium chloride

DOI: 10.1002/cphc.201600308 DOI Help

Authors: Steven Kirkham (University of Reading) , Valeria Castelletto (University of Reading) , Ian W. Hamley (University of Reading) , Katsuaki Inoue (Diamond Light Source) , Robert Rambo (Diamond Light Source) , Mehedi Reza (Aalto University) , Janne Ruokolainen (Aalto University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemphyschem

State: Published (Approved)
Published: April 2016

Abstract: The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaClâ‚‚, in contrast to claims in the literature that CaClâ‚‚ is required for micellization.

Diamond Keywords: Bacteria

Subject Areas: Chemistry, Medicine

Instruments: B21-High Throughput SAXS

Added On: 06/04/2016 16:07

Discipline Tags:

Pathogens Antibiotic Resistance Infectious Diseases Physical Chemistry Health & Wellbeing Biochemistry Chemistry Organic Chemistry Life Sciences & Biotech

Technical Tags:

Scattering Small Angle X-ray Scattering (SAXS)