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Langmuir monolayers composed of single and double tail sulfobetaine lipids

DOI: 10.1016/j.jcis.2016.04.020 DOI Help

Authors: Gavin Hazell (University of Bath) , Anthony P. Gee (University of Bath) , Tom Arnold (Diamond Light Source) , Karen J. Edler (University of Bath) , Simon E. Lewis (University of Bath)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Colloid And Interface Science , VOL 474 , PAGES 190 - 198

State: Published (Approved)
Published: July 2016
Diamond Proposal Number(s): 9909

Open Access Open Access

Abstract: Owing to structural similarities between sulfobetaine lipids and phospholipids it should be possible to form stable Langmuir monolayers from long tail sulfobetaines. By modification of the density of lipid tail group (number of carbon chains) it should also be possible to modulate the two-dimensional phase behaviour of these lipids and thereby compare with that of equivalent phospholipids. Potentially this could enable the use of such lipids for the wide array of applications that currently use phospholipids. The benefit of using sulfobetaine lipids is that they can be synthesised by a one-step reaction from cheap and readily available starting materials and will degrade via different pathways than natural lipids. The molecular architecture of the lipid can be easily modified allowing the design of lipids for specific purposes. In addition the reversal of the charge within the sulfobetaine head group relative to the charge orientation in phospholipids may modify behaviour and thereby allow for novel uses of these surfactants.

Subject Areas: Chemistry, Biology and Bio-materials, Physics

Diamond Offline Facilities: Spectroscopic Imaging Ellipsometer / Brewster Angle Microscope (Nanofilm EP3SE)
Instruments: I07-Surface & interface diffraction