Stabilisation of metastable polymorphs: the case of paracetamol form III

DOI: 10.1039/C6CC05006A

Authors: Richard Telford (University of Bradford) , Colin C. Seaton (University of Bradford) , Alexander Clout (University College London) , Asma Buanz (University College London) , Simon Gaisford (University College London) , Gareth R. Williams (University College London) , Timothy J. Prior (University of Hull) , Chidera H. Okoye (University of Lincoln) , Tasnim Munshi (University of Lincoln) , Ian J. Scowen (University of Lincoln)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Communications , VOL 52 , PAGES 12028 - 12031

State: Published (Approved)
Published: September 2016
Diamond Proposal Number(s): 10503 , 12735

Abstract: The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

Subject Areas: Medicine, Chemistry, Biology and Bio-materials


Instruments: I12-JEEP: Joint Engineering, Environmental and Processing

Added On: 12/10/2016 10:17

Documents:
C6CC05006A.pdf

Discipline Tags:

Biochemistry Chemistry Organic Chemistry Life Sciences & Biotech

Technical Tags:

Diffraction X-ray Powder Diffraction