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Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems

DOI: 10.1021/acs.langmuir.6b02927 DOI Help

Authors: Gavin Hazell (University of Bath) , Thomas Arnold (Diamond Light Source) , Robert D. Barker (School of Science and Engineering, University of Dundee) , Luke A. Clifton (ISIS) , Nina-juliane Steinke (ISIS) , Cecilia Tognoloni (University of Bath) , Karen J. Edler (University of Bath)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Langmuir

State: Published (Approved)
Published: November 2016

Open Access Open Access

Abstract: Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid–liquid or air–liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.

Subject Areas: Biology and Bio-materials, Chemistry, Physics


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