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Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization

DOI: 10.1021/acs.orglett.6b02744 DOI Help

Authors: Alan D. Lamb (Chemistry Research Laboratory, University of Oxford) , Peter D. Davey (Chemistry Research Laboratory, University of Oxford) , Russell W. Driver (Chemistry Research Laboratory, University of Oxford) , Amber L. Thompson (Chemistry Research Laboratory, University of Oxford) , Martin D. Smith (Chemistry Research Laboratory, University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Organic Letters , VOL 18 , PAGES 5372 - 5375

State: Published (Approved)
Published: October 2016
Diamond Proposal Number(s): 7768

Open Access Open Access

Abstract: Functionalized 4- and 6-azaindolines are accessible with high levels of enantioselectivity by the cation-directed cyclization of aminopyridine-derived imines via phase-transfer catalysis. The extension of this methodology to diastereoselective cyclizations is also described.

Subject Areas: Chemistry


Instruments: I19-Small Molecule Single Crystal Diffraction

Documents:
acs.orglett.pdf