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Gold nanoparticles increases UV and thermal stability of human serum albumin

DOI: 10.1116/1.4972113 DOI Help

Authors: Robin Capomaccio (European Commission, DG Joint Research Centre) , Inês Osório (European Commission, DG Joint Research Centre) , Isaac Ojea-Jimenez (European Commission, DG Joint Research Centre) , Giacomo Ceccone (European Commission, DG Joint Research Centre) , Pascal Colpo (European Commission, DG Joint Research Centre) , Douglas Gilliland (European Commission, DG Joint Research Centre) , Rohanah Hussain (Diamond Light Source) , Giuliano Siligardi (Diamond Light Source) , Francois Rossi (European Commission, DG Joint Research Centre) , Sylvie Ricard-Blum (CNRS-Universite Lyon 1-ICBMS) , Luigi Calzolai (European Commission, DG Joint Research Centre)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Biointerphases , VOL 11

State: Published (Approved)
Published: December 2016
Diamond Proposal Number(s): 9836 , 9064

Open Access Open Access

Abstract: Ultraviolet (UV) radiation, temperature, and time can degrade proteins. Here, the authors show that gold nanoparticles significantly protect human serum albumin from denaturation when exposed to “stressing” conditions such as UV irradiation and sustained exposure in suboptimal conditions. In particular, the authors show that gold nanoparticles significantly reduce the decrease in secondary structure induced by UV irradiation or extended exposure to ambient temperature.

Journal Keywords: Nanoparticles; Proteins; Ultraviolet light; Gold; Secondary structure

Subject Areas: Biology and Bio-materials


Instruments: B23-Circular Dichroism

Added On: 04/01/2017 13:05

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1.pdf

Discipline Tags:

Biotechnology Materials Science Engineering & Technology Nanoscience/Nanotechnology Life Sciences & Biotech

Technical Tags:

Spectroscopy Circular Dichroism (CD)