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High-throughput SRCD using multi-well plates and its applications

DOI: 10.1038/srep38028 DOI Help

Authors: Rohanah Hussain (Diamond Light Source) , Tamas Javorfi (Diamond Light Source) , Timothy R. Rudd (Diamond Light Source) , Giuliano Siligardi (Diamond Light Source)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Scientific Reports , VOL 6

State: Published (Approved)
Published: December 2016
Diamond Proposal Number(s): 5950 , 8893 , 12182

Open Access Open Access

Abstract: The sample compartment for high-throughput synchrotron radiation circular dichroism (HT-SRCD) has been developed to satisfy an increased demand of protein characterisation in terms of folding and binding interaction properties not only in the traditional field of structural biology but also in the growing research area of material science with the potential to save time by 80%. As the understanding of protein behaviour in different solvent environments has increased dramatically the development of novel functions such as recombinant proteins modified to have different functions from harvesting solar energy to metabolonics for cleaning heavy and metal and organic molecule pollutions, there is a need to characterise speedily these system.

Journal Keywords: Biomaterials; High-throughput screening; Molecular conformation

Subject Areas: Technique Development, Materials, Biology and Bio-materials

Instruments: B23-Circular Dichroism

Added On: 04/01/2017 13:47


Discipline Tags:

Biotech & Biological Systems Biomaterials Technique Development - Life Sciences & Biotech Materials Science Life Sciences & Biotech

Technical Tags:

Spectroscopy Circular Dichroism (CD)