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A combined X-ray scattering and simulation study of halothane in membranes at raised pressures

DOI: 10.1016/j.cplett.2016.12.041 DOI Help

Authors: N. L. C. Mccarthy (Imperial College London) , N. J. Brooks (Imperial College London) , A. I. I. Tyler (Imperial College London) , Mohammad Elgamacy (Max-Planck-Institut für Entwicklungsbiologie) , P. R. L. Welche (University of Cambridge) , M. C. Payne (University of Cambridge) , P.-l. Chau (Institut Pasteur)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemical Physics Letters

State: Published (Approved)
Published: January 2017
Diamond Proposal Number(s): 6527 , 9557

Abstract: Using a combination of high pressure wide angle X-ray scattering experiments and molecular dynamics simulations, we probe the effect of the archetypal general anaesthetic halothane on the lipid hydrocarbon chain packing and ordering in model bilayers and the variation in these parameters with pressure. Incorporation of halothane into the membrane causes an expansion of the lipid hydrocarbon chain packing at all pressures. The effect of halothane incorporation on the hydrocarbon chain order parameter is significantly reduced at elevated pressure.

Journal Keywords: X-ray scattering; Molecular dynamics simulations; Halothane; DMPC; General anaesthetics; Pressure reversal

Subject Areas: Chemistry, Medicine

Instruments: I22-Small angle scattering & Diffraction

Added On: 10/01/2017 09:05

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