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Highly enantioselective synthesis of alkyl-pyridines derivatives through a Michael-Michael-aldol cascade reaction

DOI: 10.1002/ejoc.201601491 DOI Help

Authors: Marta Meazza (University of Southampton) , Michael Potter (University of Southampton) , Mateusz Pitak (University of Southampton) , Simon Coles (University of Southampton) , Andrea Mazzanti (University of Bologna) , Ramon Rios Torres (University of Southampton)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: European Journal Of Organic Chemistry

State: Published (Approved)
Published: November 2016
Diamond Proposal Number(s): 8521

Abstract: A new methodology for the synthesis of pyridine derivatives based on a triple cascade reaction catalyzed by chiral secondary amines. The resulting cyclohexenes (3 C-C bond were formed) were obtained in good yields, good diastereoselectivities and excellent enantioselectivity

Journal Keywords: Organocatalysis; Azaarenes; quaternary stereocenter; enantioselective; Cascade reactions

Subject Areas: Chemistry, Technique Development

Instruments: I19-Small Molecule Single Crystal Diffraction

Added On: 18/01/2017 10:42

Discipline Tags:

Physical Chemistry Technique Development - Chemistry Catalysis Chemistry Organic Chemistry

Technical Tags:

Diffraction Single Crystal X-ray Diffraction (SXRD)